NMR-Bildgebung des Herzens und kardiale Biophysik

Development of NMR techniques to quantify myocardial microcirculation
(perfusion,capillary volume, oxygenation), cardiac function and ion homeostasis
(see also our webpage: "MRT und Biophysik")

many cardiac diseases as hypertrophy of coronary artery disease are related to alterations of myocardial microcirculation. However there are only few techniques to quantify microcirculation . NMR-imaging has the potential to visualise microcirculation. The first step is the development of a model which relates the biophysical parameter of microcirculation to some NMR parameter. The second step is the development of an imaging sequence which precisely measures this NMR-parameter, despite the many obstacles in cardiac imaging. The last step is the validation with an established technique, as far as such a technique exists.

Example 1

Perfusion measurement without contrast agent Perfusion is defined as: Volume blood/time/Volume (or mass) tissue. The longitudinal relaxation time T1 is a function of perfusion when spins within the imaging slice are selectively prepared (inverted or saturated). The maps below show the cross sections of a rat with the short axis view of the heart. From the two T1-maps a perfusion map is obtained.

Almost non perfusion sensitive T1 map after global spin inversion

Perfusion sensitive T1 map after slice selective spin inversion
Perfusion map
Perfusion map